|
Evaluation of Anti-Inflammatory Activity of Solanum nigrum Infused Selenium Nanoparticles - An In Vitro Study
|
|
| Author:
|
KIRTANA GOPALASAMY, JAIGANESH RAMAMURTHY
|
| Abstract:
|
Background: Nanotechnology has been emerging as an interdisciplinary field that is undergoing rapid development and has brought enormous changes in dentistry. Solanum Nigrum is a medical plant with high antimicrobial and antiinflammatory properties. Since periodontal diseases occur as a result of inflammatory processes, this vitro study has been done to evaluate the anti-inflammatory activity of solanum nigrum extract and its based selenium nano formulations to incorporate into periodontics.
Materials and Method: The collection and preparation of solanum nigrum extract was done and stored for further use. Synthesis of selenium nanoparticles was done with the addition of glacial acetic acid along with selenium nitrate. Centrifugation was done and characterisation of selenium nanoparticles using ultraviolet (UV)-vie-spectroscopy spectroscopy. The anti-inflammatory activity of selenium nanoparticles was measured and compared using the standard diclofenac sodium assay.
Results: The anti-inflammatory activity of solanum nigrum infused selenium nanoformulation increased with increase in concentrations. At 30uL, 40uL Selenium nanoparticles showed a higher antiinflammatory activity than standard, Selenium has better anti-inflammatory activities at higher concentrations when compared to standard diclofenac sodium.
Conclusion: Selenium Nanoparticles have better anti-inflammatory activity when compared to S.nigrum infused Selenium nanoformulations. Further formulations of solanum nigrum with other nanoparticles in various forms such as gel and microspheres can be potentially used for controlled drug delivery in the treatment of periodontitis.
|
| Keyword:
|
Anti Inflammatory; Selenium; Herbal; Solanum Nigrum; Nanosynthesis
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP1.426
|
| Download:
|
Request For Article
|
|
|