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Anti-Inflammatory and Cytotoxic Activity of Silver Nanoparticles Prepared from Horseradish Oil –An In Vitro Approach
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| Author:
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MAAJIDA AAFREEN M, ANITHA ROY, S. RAJESHKUMAR, DR. LAKSHMI THANGAVELU
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| Abstract:
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Aim: The aim of the study was to evaluate the anti-inflammatory and cytotoxic potential of horseradish oil mediated silver nanoparticle.
Materials and method: The Silver nanoparticles were synthesised using horseradish oil and was confirmed by UV- Visible spectroscopy. The synthesised silver nanoparticles were evaluated for its anti-inflammatory activity by studying the inhibitory effect on albumin denaturation assay. The cytotoxic activity of silver nanoparticles were examined by the brine shrimp lethality assay.
Result: The silver nanoparticles prepared from horseradish oil showed good anti-inflammatory. The silver nanoparticles were analysed using UV -Visible Spectrophotometry and were found in the absorbance range of 200nm to 540nm. The peak was found to be at the maximum at 300nm. The synthesised nanoparticle showed maximum anti-inflammatory activity with 96% of inhibition at a concentration of 10µL. The study did not show any cytotoxic activity.
Conclusion: In the present study it has been observed that the silver nanoparticles prepared from horseradish oil have very good anti-inflammatory properties and did not exhibit any cytotoxic activity. Biosynthesis of nanoparticles using horse radish oil was ecofriendly, reliable and suitable. They can also be used for large scale production. It was easy to handle and is a rapid process. Hence horseradish oil mediated silver nanoparticles may be used as a better option for using against various inflammatory diseases
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| Keyword:
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nanoparticles, nanotechnology, horseradish oil, cytotoxic, anti-inflammatory.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.408
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| Download:
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