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Plasma Levels of Cytokines (IL-10) in Multidrug Resistant Tuberculosis– A literature review
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| Author:
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IRAWATY DJAHARUDDIN, MUZAKKIR AMIR, SRI RAMADANI, ETIEN ANDRIYANI, DICKY WAHYUDI
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| Abstract:
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Objective: Interleukin-10 (IL-10), interferon gamma (IFN-?) and tumour necrosis factor (TNF-a) play very important roles in anti-TB cell-mediated immunity, in both MDR-TB and drug-susceptible TB (DS-TB) patients.
Method: The databases used were PubMed and ScienceDirect. The keywords for the search were “Interleukin-10” AND “MDR-TB”. The inclusion criteria was review articles and research articles published between January 2015 until August 2020 in free full text English.
Results: IL-10 plays an important role in suppressing macrophage and dendritic cell (DC) function, which helps control and initiate the immune responses. IL-10, which is a suppressor T cell or T-regulatory cytokine, is known to play a critical role during chronic and latent stages of pulmonary TB [53]. The IL-10 production is said to be elevated during the infection, promoting reactivation of TB [54]. The excessive production of this cytokine usually results in failure to control the infection, and this could account for why IL-10 was elevated in the MDR-TB participants.
Conclusions: IL-10 production in MDR-TB might also indicate suppression of the immune response, leading to an inadequate balance of pro- and anti-inflammatory cytokines.
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| Keyword:
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IL-10, MDR-TB
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.374
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| Download:
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Request For Article
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