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Changing faces of organs pathophysiology in ACE-2 bonded SARS-CoV-2 infection: What says the recent literature?
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| Author:
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, DEBENDRA NATH ROY, NOWRIN FERDIOUSI, ASMA AKTAR, MOSHARRAF HOSSAIN
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| Abstract:
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Background and Aims: The SARS-CoV-2 infected disease called COVID-19 is a major threat to human beings and has rapidly become the foremost public health crisis worldwide. In addition to severe respiratory symptoms, organs pathophysiological changes are growing concern observed in clinical settings. Irregular pathological findings seen to COVID-19 patients are becoming more serious issues and created severe complications during treatment period. This review is aimed to examine and analyze the relevant clinical data of organs pathological changes due to the strong affection of SARS-CoV-2 with ACE-2 receptor in sites.
Methods: In this systematic review, we used the PRISMA Diagrammatic approach of the literature search strategy and the reputed electronic databases were reviewed to assess these changing patterns of organs pathology in SARS-CoV-2 infection.
Results: Our findings revealed that, due to the vast appearance of Angiotensin Converting Enzyme-2 (ACE-2) in the epithelial cells of all major organs including heart, pancreas, liver, lungs, kidney, brain and blood cells in the human body makes them prominent binding targets of SARS-CoV-2 infection resulting into clusters of illness onsets. Significant changes of organs pathophysiological values in COVID-19 leads to multiple organ injuries and sometimes caused to death. The COVID-19 has impacted adversely on transiting these organs pathological margins beyond their usual normal limits during the incubation periods.
Conclusions: Given the emphasis of urgency, this research contribute to the knowledge gaps of health professionals on the COVID-19 induced organs pathological changes which in turn ensure the best quality management protocol associated with clinical crisis of COVID-19 treatment.
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| Keyword:
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SARS-CoV-2; ACE-2; Organs; Pathophysiology; Infection.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.367
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| Download:
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