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Effect of EGb 761 (Tanakan) Therapy in Eyes with Non-proliferative Diabetic Retinopathy.
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| Author:
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GUZAL KANGILBAEVA, AZIZA JURABEKOVA
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| Abstract:
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Tanakan - standardized extract of Ginkgo biloba (EGb 761) has a wide spectrum of pharmacological activity, which allows it to meet numerous pathological requirements - hemodynamic, hemorheological, metabolic. The study aimed to assess the effectiveness of Tanakan endonasal electrophoresis therapy for non-proliferative diabetic retinopathy (NPDR). Patients (165) were randomized 1:1:1 to three groups by 55 each and observed within 6 months. The control group patients received standard therapy for 10 days. The first main group patients received additional Tanakan (EGb 761) in tablets (TT-group) for 10 days. The second main group patients instead of Tanakan in tablets received endonasal electrophoresis by Tanakan (TE-group) for 10 days. Improvement DR 2-steps or more was observed in 27%, 57%, and 0% eyes of the TT-group, TE-group, and control-group respectively at month 6. More than 43% of the control group patients had a 2-steps or more worsening in their DR severity at month 6. Mean retinal photosensitivity deviations decreased by 25% in the TE group, while in the control and TT groups only by 16% and 21%, respectively. This study demonstrated the need for early Tanakan endonasal electrophoresis therapy for DR to achieve the most effectively reduce the risk of progression to the proliferative stage.
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| Keyword:
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diabetic retinopathy severity, Ginkgo biloba, antioxidant therapy, endonasal electrophoresis, nonproliferative diabetic retinopathy, retinal photosensitivity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.317
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| Download:
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