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Article Detail
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Evaluation of Serum Adropin Levels in Nonalcoholic Fatty Liver Disease as A Complication of Hypothyroidism In Iraqi Patients
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| Author:
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MARWAH.SABAH ALTAIEE, TAGHREED. ULOOM. MOHAMMED, ANMAR DHIA ALDEEN MUHSIN
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| Abstract:
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Adropin play an important role in metabolic homeostasis, such as controlling fatty acid metabolism and preventing insulin resistance, dyslipidemia, and impaired glucose tolerance. Non-alcoholic fatty liver disease (NAFLD) can lead to functional liver impairment and severe comorbidities. NAFLD can progress into steatohepatitis, which may cause progressive liver damage, leading to cirrhosis and hepatocellular carcinoma. Since NAFLD is associated with metabolic risk factors, e.g., dyslipidemia, insulin resistance, hypertension, visceral obesity, it is considered as the hepatic manifestation of the metabolic syndrome.
The objective of this study was to determine serum Adropin levels in hypothyroid patients with fatty liver disease and in hypothyroid patients without fatty liver disease and to compare the results with control groups, and also to study the relationship of S. Adropin levels with the Anthropometric and Clinical Features (Age, Gender, BMI and Duration of Hypothyroidism) , Serum Thyroid Hormones (T3, T4 and TSH) Lipid profile (Serum Cholesterol, TG and HDL), Liver Enzymes (GOT , GPT and ALP )Levels , Renal Function Tests (blood Urea and serum Creatinine), Glycemic Parameters (F.B.S and HbA1c levels), Serum Hematological Parameters (PCV, MCV and WBC) and Serum Protein Parameters (Total Protein, serum albumin and serum Ferritin) levels. Ninety individuals participated in this study and classified into three groups: G1: Hypothyroidism with fatty liver disease patients, G2: Hypothyroidism without fatty liver disease patients and G3: control subjects. All study cases were chosen from the Specialized Center of Endocrinology and Diabetes in Baghdad/ Alrisafa side. The age ranges of G1, G2 and G3 were (32-64), (23-67) and (24-40) years, respectively. Gender distribution shows increase in females to males in all the studied groups. This can be explained by the higher incidence and prevalence of hypothyroidism in females compared to males. The results demonstrated that the mean values of serum Atropine in G1 (469.113±391.984 pg/ml) and G2 (561.037±476) were significantly decreased (P=0.0001) compared with the mean serum Adropin in G3(2919.73±316.86 pg./ml),While the mean value of serum Adropin in G1 (469.113±391.984 pg./ml) was slightly decreased compared with the mean value of serum Adropin in G2 (561.073±476.819 pg/ml. Also the study included the Receiving Operating Characteristic (ROC) curves analysis for serum Adropin levels, when used as a test to diagnose subjects into cases and control, and a determination of the “cut-off value” which has the optimum sensitivity and specificity to diagnose the disease was performed.
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| Keyword:
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Adropin , Non-Alcoholic Fatty liver disease , Hypothyroidism , ROC analysis .
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.363
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| Download:
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