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Intra Nasal Drug Delivery an Alternative Route for Brain Targeting-A Review
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| Author:
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NIRANJAN BABU.M, CHANDRASEKAR R
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| Abstract:
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Chronic pain syndrome is a severe disorder which includes fibromyalgia, rheumatoid arthritis, cancer related pain and several other pains. Pains are very severe in the age above 60 like rheumatic pains. The prevalence of chronic pain is high in developed and developing countries. There is a significant increase in chronic pain prevalence studies in the world. Chronic pain is severe condition were treatments are offered with NSAID’s, topical formulations, sprays. These medications can offer only a temporary relief. There is no permanent relief for chronic pains. Pain is an immune mediated disorder which leads to sleeplessness, stress, tired. Normally chronic pains cannot be cured by treatment with modern medicines, but they are available with severe toxic effects. Treatments are available with pain relievers which may give a temporary relief but with severe side effects. Treatments with herbal remedies are available with essential oils as a combination of different essential oils which can be used as an oil bath these oils can relieve pain to some extent and can give a relief to patients with chronic pain. Hence when a natural product containing essential oil is selected the compound must contain phytoconstituents which include many secondary metabolites such as alkaloids, glycosides, terpenoids and steroids. The selected compound must be free from side effects and toxicity, should be having better potency and efficacy and safe to use. Nasal sprays are agents which can deliver medicaments directly to the brain by targeting pain receptors in the brain. Nasal sprays are more efficient way of administering drugs with potential use in crossing the blood–brain barrier. This review mainly focuses on intra nasal drug delivery and transport of drugs through the olfactory route and also reviews the recent development in nanotechnology and role of Nanoparticles used in the nose-to-brain drug delivery.
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| Keyword:
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Intranasal Drug Delivery, Chronic Pain Syndrome, Essential oil, Nanoparticles
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.358
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| Download:
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