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Understanding the interaction of excipient binary mixture on pre-tableting properties
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| Author:
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AHMAD AINUROFIQ, SYAIFUL CHOIRI, SAPTONO HADI, DINAR S. C. WAHYUNI, RITA RAKHMAWATI, NESTRI HANDAYANI, ESTU R. NUGRAHENI
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| Abstract:
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Herein, we revealed the effect and interaction of commonly used excipients as binary mixtures on pre-tableting properties e.g. flow characteristics, drying kinetics, and homogeneity alteration during mixing process. Commonly used excipients on tablet preparation e.g. lactose, starch, microcrystalline cellulose, and dicalcium phosphate were studied. The single component and binary mixture of those excipients were granulated using a wet granulation technique. Thereafter, the flow characteristics was evaluated by flow rate and angle of repose. For further evaluation, the drying kinetics parameters i.e. moisture content and loss on drying were assessed. The mixing behavior through different mechanisms e.g. random and ordered mixing mechanisms was applied using acetaminophen and micronized nifedipine as drug models, respectively. The results showed that the dicalcium phosphate could be applied for flow properties enhancement. Meanwhile, the starch-based combination had a high tendency to retain water and it can be modified through interaction with other excipients. The mixing kinetics in random or ordered mixing mechanisms had no different pattern among all excipient combinations. Finally, the interaction of excipients should be understood thoroughly in order to enhance the efficiency of manufacturing process due to altering the native features of excipient performance.
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| Keyword:
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tablet, excipient, lactose, starch, Avicel
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.349
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| Download:
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