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New Validated Method For The Estimation Of Capecitabine In Pharmaceutical Dosage Forms By Area Under Curve Processing Technique
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| Author:
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KARAJGI S.R, SOMASHEKHAR M, POOJA CHINCHOLI, LAXMI S.DEGINAL, MHETRE BHOURAMMA, PRABHAVATI MIRJI, KULKARNI R.V
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| Abstract:
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An easy, fast, precise and cost effective uv method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The area on the UV-spectrum between 295nm and 305nm in distilled water as the solvent was found to be suitable for the measurement of Capecitabine with a Linearity range throughout the concentrations of 40 microgram/ml to 80 microgram/ml. The method was successfully employed for the routine estimation on tablet dosage forms. The method was validated according to ICH guidelines. No interference from additives was observed.
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| Keyword:
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Capecitabine, estimation, area under curve, analytical method
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.335
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| Download:
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