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“Central Nervous System Depressant effects and Muscle relaxant activity of Galphimia gracilis Bartl. Stem methanol extract on Swiss albino mice”
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| Author:
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, GARIGE BABA SHANKAR RAO, K. SRISAILAM, V. UMA MAHESHWARA RAO, RAM MOHAN MANDA, B. VASUDHA
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| Abstract:
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The Galphimia gracilis Bartl. is used traditionally in conditions of anxiety, fear, stress, phobia and to bring a calming effect on the nerves. This study assesses the central nervous system depressant and muscle relaxant effects of G. gracilis stem methanol extract (GgSME). The GgSME was administered in Swiss albino mice in one day to animal models like Sodium pentobarbital induced sleep test, Open field test, Hole-board test, Picrotoxin induced convulsions, Pentylenetetrazole induced convulsions, Rota rod test and Grip strengthening test. The LD¬50 value of the GgSME was noticed to be > 2000 mg/kg. Mice treated with GgSME at 100, 200 and 400 mg/kg doses lengthened the duration of sleep induced by sodium pentobarbital (40 mg/kg, i.p.). The GgSME at 400 mg/kg dose produced a significant (P = 0.001) sedative behavior in the hole-board test and drop off spontaneous activity in animals and also slowed the outset of seizures induced by Pentylenetetrazole (90 mg/kg, i.p) & by Picrotoxin (10 mg/kg, i.p). In open field test, there was a drop of the rearing and voluntary movements (P = 0.001) in animals treated with GgSME. The GgSME also displayed significant (P = 0.05) effects on muscle relaxant activity in both Rota rod test and Grip strengthening test. The overall results conclude that the GgSME has significant CNS depressant actions and muscle relaxant effects.
Abbreviations: Gg, Galphimia gracilis; IAEC, Institutional Animal Ethics Committee; GgSME, Galphimia gracilis stem methanol extract; CPCSEA, Committee for the Purpose of Control and Supervision of Experimental Animals; b.w, Body weight; i.p, Intraperitoneal; per os, by mouth or orally; OECD, The Organization for Economic Co-operation and Development; AGI, Anurag Group of Institutions.
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| Keyword:
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Hole-board test, Convulsions, Mice, Open field test, Picrotoxin, Pentylenetetrazole
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.319
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| Download:
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Request For Article
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