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Importance of Herbal Antioxidant in Management of Parkinson's Disease
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| Author:
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YATENDRA SINGH, MADAN KAUSHIK, PREETI VERMA, PEEYUSH
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| Abstract:
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Parkinson’s disease (PD) or paralysis agitans, is disorder of extrapyramidal system which is manifested by shortage of chemical messenger ‘dopamine’ in the basal ganglion. Generally, it affects 1 in 200 elderly population. Clinical Features of the disease is mostly due to continuous degenerative loss of nigrostriatal dopaminergic neurons. In PD dopaminergic cells die in Substantia nigra and Corpus striatum due to involvement of genetic vulnerability, environmental factors, proteosomal dysfunction and oxidative stress, most of which have yet to be identified. Pathogenesis of this syndrome is not clearly established and it is incurable in present. The current symptomatic treatment has failed to improve the life of PD patients. New therapeutic approaches is required to stop the disease progression. Oxidative stress is one of the major factors that are responsible for worsening the symptoms of PD. None of the current drug regimens can stop this oxidative stress. Herbal antioxidants has proven its effectiveness in PD by suppressing oxidative stress. This review examines the currently published literature on the utilization of natural herbal bioactive molecule on the management of PD along with involvement of oxidative stress in pathogenesis of PD.
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| Keyword:
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Parkinson’s disease, Herbal antioxidant, Oxidative stress, Dopamine
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.351
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| Download:
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