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Acute Inflammatory Response after Bioresorbable Coronary Scaffold Implantation and impact of Trimetazidine
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| Author:
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HUSSEIN A.ALSALKHI, AHMED N. RAJEEB, MUSTAFA H. AHMED, NAJAH R. HADI, KHALID I. AMBER, BASHAER M. MUHAMMAD-BAQIR
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| Abstract:
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Background: Coronary intervention is related to local vascular and systemic inflammation that leads to the stimulation of inflammatory reaction, caused by the rupture of the atherosclerotic plaque and the tunica media fallowing extension of the stent and insertion of a metallic foreign body. Arterial wall damage occurs in addition to the release of inflammatory and chemoattractant factors which stimulate an inflammatory response, leading to leukocyte and platelet activation. Bioresorbable vascular Scaffold (BVS) is considered the fourth revolution in interventional cardiology. It has introduced a novel technology in the treatment of coronary artery disease (CAD). Trimetazidine (TMZ) is an anti-ischemic agent which minimizes the myocardial damage induced by the percutaneous coronary intervention (PCI).
Objective: To assess the effect of TMZ on the acute inflammatory response after BVS implantation in patients with CAD.
Patients and Methods: A total of 40 diabetic patients with stable coronary artery disease were assigned into two groups: the control group and TMZ treated group. Both groups were admitted to AL-Najaf center for cardiac surgery and Tran’s catheter therapy. Thus, patients under went elective coronary scaffold implantation. Serum blood was collected from peripheral vein before implantation, 12 hrs and 24 hrs after implantation. Collected samples were used to measure IL-8, hs-CRP, cTn-I, MMP-9 and VCAM-1 levels by sand wichELISA method in addition to determine the WBC count.
Results. Scaffold implantation produced significant changes in serum levelIL-8, hs-CRP, cTn-I, WBC and VCAM-1(p<0.05).However, no significant change in serum level MMP-9was found (p>0.05).On the other hand, TMZ treatment produced a significant decrease in cTn-I, hs-CRP levels and the WBC count (p<0.05).No significant changes in serum IL-8, MMP-9and VCAM-1were found (p>0.05).
Conclusion: Trimetazidine reduced the systemic inflammatory response induced by implantation of Bioresorbable coronary scaffold.
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| Keyword:
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Coronary artery disease, percutaneous coronary intervention, inflammatory response, Novolimus eluting Bioresorbable coronary scaffold, inflammatory markers, Trimetazidine.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.348
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| Download:
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