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Synthesis of New Derivatives of Pyrazolone Compounds
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| Author:
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, BANAN BORHAN SAEED, NAGHAM M. ZAKI DAWOOD, ZAHRAA SEDEEQ QASIM
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| Abstract:
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The Non-steroidal anti-inflammatory drugs [NSAIDs] are acidic either by carboxyl or phenolic groups, which used to date such us mefenamic acid, naproxen, diclofenac, indomethacin, ibuprofen, and aspirin. To minimize the harmful effects of the free group of carboxylic acids found in these NSAIDs on the stomach, 4-Aminoantipyrin (which has analgesic, anti-inflammatory, and antipyretic properties) was selected with six standard non-steroidal anti-inflammatory drugs to change their chemical formulations to obtain a dual suggested drug. The goal of the present research, is to synthesize a new potential non-steroidal anti-inflammatory agents with 4-Aminoantipyrine. These proposed new compounds have been prepared by converting NSAIDs into the corresponding acid chlorides, then treating them directly with 4-amino antipyrin to provide amides (1-6) and thus protecting the stomach from the group of carboxylic acids that may cause stomach ulcers in addition to producing new prodrugs, and identified their physical and spectroscopic FTIR, and NMR properties. Also, our results indicate that compounds containing Antipyrin-NSAIDs moiety have great potential in developing a wide variety of new antibacterial against two Gram (+)ve and three Gram (-)ve bacteria.
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| Keyword:
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Antipyrin, NSAIDs, amides, biological activity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.342
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| Download:
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