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Development and evaluation of floating microsphere based gastroretentive formulation of acarbose
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| Author:
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UMASHREE KOKATANUR, J. K. SABOJI, A. A. KEMPAWADE, R. D. HIREMATH, ARCHANA S. PATIL
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| Abstract:
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Background: Acarbose is an oral antidiabetic (a-glucosidase inhibitor) drug used in the treatment of type II diabetes. Acarbose has half-life less than 2h and absorption window at brush border of small intestine. Objectives: The objective of the present study was to enhance the site specific activity, prolong the duration of action and improve therapeutic efficacy of drug by formulating as a gastro retentive floating drug delivery system. Methodology: Gastroretentive floating microspheres of Acarbose were formulated and optimized with respect to quantity of polymer and stirring speed to get optimum buoyancy and drug release rate. The microspheres were characterized for their particle size, buoyancy, drug encapsulation efficiency and in-vitro drug release rate. Results: The buoyancy, encapsulation efficiency and in-vitro drug release rate of formulations (F1-F9) was varied from 67.12±1.3 to 89.12±1.8, 78.8±1.7 to 98.12±1.5 and 69.53±1.7 to 89.12±1.8 respectively. Conclusion: The present study concludes that floating microspheres based Gastroretentive drug delivery system of Acarbose is a safe and effective drug delivery system with improved site specificity and prolonged duration of action of drug and also improves the therapeutic efficacy of drug.
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| Keyword:
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Floating microspheres; Acarbose; Type II diabetes; Gastroretentive drug delivery.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.161
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| Download:
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