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An Overview of Pulmonary Adenoid Cystic carcinomas - Review Article
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| Author:
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BARANI KARIKALAN, SRIKUMAR CHAKRAVARTHI
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| Abstract:
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Pulmonary adenoid cystic carcinoma (PACC) is one of the commonest salivary gland type tumors to occur in the lung. Although PACC is considered as a low grade malignancy, it tends to be missed out and diagnosed in an advanced stage, these tumors are mostly unresectable. If resected, they tend to have positive margins leading to recurrence of the lesion. Owing to the rarity of the lesion, only a limited amount of case series have been published in literature and hence remain less described. Accurate prediction of overall survival is not possible but so far reported studies show poor overall survival. Non association with smoking and younger age groups in comparison with other lung malignancies are notable demographic features of the tumor. Radiology seldom helps in diagnosis. Histopathological features are essential for diagnosis and immunohistochemistry aids in confirmation. Surgery is the preferred treatment of choice in localised disease while adjuvant radiotherapy and palliative chemotherapy are being studied to recurrent and advanced diseases respectively. Genetic profile of PACC is found to be different from other conventional lung malignancies. Aggressive nature of PACC warrants more studies to identify target genes that might help increase overall survival of the affected patients. In this article, we reviewed previously reported case series’ and case reports of PACCs, in an attempt to describe and summarize the clinical features, management modalities and outcomes of PACC along with emphasis on possibility of target therapy.
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| Keyword:
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Adenoid cystic carcinoma, Lung, Pulmonary, Target therapy, Genetic alterations, Molecular markers
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.006
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| Download:
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