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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Sodium selenite inhibits paw edema and activity of peritoneal macrophages cells in mice

Author: MUHAMMAD HASAN BASHARI, ULIA RAMADHANTI, UTARI HARTATI SURYANI, JAMAS ARI ANGGRAINI, MARIO ROEHIMAT, FAHRANI IMANINA, RIZKY ABDULAH, AFIAT BERBUDI
Abstract: Purpose: Sodium selenite is a micromolecule that demonstrates various activities including anti-inflammatory and anti-oxidative effects. The effect of sodium selenite on macrophage phagocytic activity is still inconsistent. This study was aimed at identifying the effect of sodium selenite on the carrageenan-induced acute paw inflammation on mice model and the phagocytic activity of the macrophage in in vitro study. Methodology: The experiment was performed in female mice (Mus musculus) with two sub-studies. The first study was conducted on carrageenan-induced acute paw inflammation on mice model. The second was on isolated peritoneal macrophages from mice. Dexamethasone was used as positive control. Statistical analysis was analyzed using ANOVA test. Results: Our data showed that both sodium selenite and dexamethasone prevented paw edema compared to control (p<0.05). In contrast, distribution of polymorphonuclear (PMN) and mononuclear (MN) cells 24 hours after induction of inflammation were not different among the groups. Moreover, as expected, both sodium selenite and dexamethasone produced similar phagocytic activity on macrophages. Applications: Sodium selenite has a comparable effect with dexamethasone on preventing paw edema, recruiting immune cells as well as inducing phagocytic activity on macrophages.
Keyword: OX,CTL
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