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Sodium selenite inhibits paw edema and activity of peritoneal macrophages cells in mice
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| Author:
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MUHAMMAD HASAN BASHARI, ULIA RAMADHANTI, UTARI HARTATI SURYANI, JAMAS ARI ANGGRAINI, MARIO ROEHIMAT, FAHRANI IMANINA, RIZKY ABDULAH, AFIAT BERBUDI
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| Abstract:
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Purpose: Sodium selenite is a micromolecule that demonstrates various activities including anti-inflammatory
and anti-oxidative effects. The effect of sodium selenite on macrophage phagocytic activity is still inconsistent.
This study was aimed at identifying the effect of sodium selenite on the carrageenan-induced acute paw
inflammation on mice model and the phagocytic activity of the macrophage in in vitro study.
Methodology: The experiment was performed in female mice (Mus musculus) with two sub-studies. The first
study was conducted on carrageenan-induced acute paw inflammation on mice model. The second was on
isolated peritoneal macrophages from mice. Dexamethasone was used as positive control. Statistical analysis
was analyzed using ANOVA test.
Results: Our data showed that both sodium selenite and dexamethasone prevented paw edema compared to
control (p<0.05). In contrast, distribution of polymorphonuclear (PMN) and mononuclear (MN) cells 24 hours
after induction of inflammation were not different among the groups. Moreover, as expected, both sodium
selenite and dexamethasone produced similar phagocytic activity on macrophages.
Applications: Sodium selenite has a comparable effect with dexamethasone on preventing paw edema,
recruiting immune cells as well as inducing phagocytic activity on macrophages.
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| Keyword:
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OX,CTL
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| EOI:
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| DOI:
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