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Anti-inflammatory effect of tabat barito (Ficus deltoidea) leaf extract on DSS-induced mice colon
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| Author:
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KUSMARDI KUSMARDI, AFRA INTAN NURLAILI , ARYO TEDJO
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| Abstract:
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Purpose: To confirm that Ficus deltoidea leaf extract has an anti-inflammatory effect on DSS-induced mice colon.
Methodology: This study was conducted using 24 stored tissue samples from previous study which are divided
into four groups: negative control (DSS), positive control (aspirin), 25% Ficus deltoidea leaf extract, and 50%
Ficus deltoidea leaf extract. Colon tissue histology sample is stained with hematoxylin-eosin (HE) staining and
examined on magnification of 40 x 10. Counted results of inflammation focus, angiogenesis, and goblet cells per
crypt are analysed with ANOVA test and Bonferroni post hoc test with 20th version of SPSS software.
Results: There is a significant increase number of goblet cells on the Ficus deltoidea leaf extract group at a
concentration of 50% (p < 0,001). However, there is no significant effect of Ficus deltoidea leaf extract on
inflammation focus and angiogenesis
Conclusion: Ficus deltoidea leaf extract has an anti-inflammatory effect as shown by the increased number of
goblet cells on the colon of DSS-induced mice.
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| Keyword:
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DSS, Ficus deltoidea
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| EOI:
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| DOI:
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