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Anticancer Activity of Selected Medicinal Plants Indigenous to Duri Ethnic
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| Author:
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ERMINA PAKKI, GEMINI ALAM , USMAR , RAHMAWATI SYUKUR , LUKMAN MUSLIMIN
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| Abstract:
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Introduction: Natural products are well recognised as sources of drugs in several human ailments. Purpose: In
the present work was carried out a preliminary screening of 32 medicinal plants indigenous to Duri Ethnic against
HeLa cell lines.
Method: In addition, the extracts were tested for their selectivity towards cancer cells (HeLa) as compared to
normal cells (Vero). The toxicity was tested by MTT assay in both cancer and normal cells at various
concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity
index (SI).
Result: The results obtained indicate that only 4 plants have a tremendous anticancer activity (IC50 < 50.00
µg/mL): Annona squamosa, Areca catechu, Macrosolen cochinchinensis, and Piper caducibracteum. While selectivity was
only found to be most favourable in A. catechu (SI= 1.24).
Value: The overall results of the present study provided evidence for the anticancer activity of A. catechu and
bring supportive data for future investigations that effective and safety in cancer therapy.
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| Keyword:
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Anticancer, Medicinal plants, Selectivity index
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| EOI:
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| DOI:
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| Download:
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