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Recent Advances In Diabetes Management Using New Oral Hypoglycemic Agents
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| Author:
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ASHWINI.K , ANITHA ROY, VINAY SIVASWAMY
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| Abstract:
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Diabetes is a chronic metabolic disorder. It is one of the most serious socio-economic crises in the world and is considered to be a serious threat to mankind. Diabetes mellitus is characterized by chronic hyperglycemia. The onset is very rapid and when it becomes uncontrolled causes stupor, coma, and even death due to ketoacidosis. The pharmacological management of diabetes is very important to control the glycemic levels. It is proven that the administration of extensive insulin therapy has improved glycemic control and its remissions. This has also reduced the mortality and morbidity of the patients. Insulin lispro is a recombinant analog similar to that of human insulin. It was found to have the greatest postprandial glycemic control. The fixed-dose combinations of different oral hypoglycemic agents are widely preferred nowadays as it reduces the economic burden of the patient. Recent advances include statin therapy with ezetimibe, daily insulin injections, noninvasive glucose sensing techniques, the role of mitochondrial miRNAs in the pathogenesis of diabetes, the role of extracts in the treatment and nanotechnology in diabetes. The non-pharmacological management of diabetes includes Mindfulness Based Stress reduction (MBSR) therapy which includes lifestyle modifications and counseling and the effect of oxidative stress in the development of insulin resistance on diabetes. The treatment modalities which we reviewed in this study have proven to have good patient outcomes. There is still a need for the development of more treatment strategies with oral hypoglycemic agents.
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| Keyword:
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diabetes; OHA therapy; oral antihyperglycemic agents; self-management
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.236
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| Download:
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