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Formulation and evaluation of pH triggered acyclovir ophthalmic In-situ gel
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| Author:
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ARCHANA S.PATIL, AISHWARYA A. PARAB, , SUJAY P. HULYALKAR, ANAND P. GADAD, PANCHAXARI M. DANDAGI, RAJASHREE S. MASAREDDY
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| Abstract:
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The poor bioavailability and therapeutic response exhibited by conventional ophthalmic preparations due to rapid precorneal elimination, dilution and nasolacrimal drainage of the drug may be vanquished by the use of in-situ gelling systems that are instilled as drops into the eye and undergo sol-to-gel transition in the cul-de-sac. The present work aims with the formulation and evaluation of an ophthalmic delivery system of an antiviral agent Acyclovir, based on the concept pH triggered in-situ gelation. Polyacrylic acid (Carbopol 974P NF) was used as gelling agent in combination of HPMC which acted as viscosity enhancing agent. Different grades of HPMC like HPMC K15M, HPMC K4M and HPMC E5LV were used. The developed formulations were evaluated for clarity, pH, drug content, gelling capacity, viscosity, in-vitro release studies, sterility test and ocular irritancy test. The results showed that the developed formulations were stable, non-irritant and provided sustained release over 8 h period, thus increasing residence time of the drug in precorneal area. Increase in residence time increases the bioavailability of the drug hence, it is considered as viable alternative to conventional eye drops of Acyclovir.
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| Keyword:
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In-situ gel, Acyclovir, Polyacrylic acid, HPMC grades.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.297
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| Download:
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