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Bioactivity of bulb from Ledebouria revoluta (L.f.) Jessop: In vitro-Antibacterial, Antioxidant, Anticancer and Larvicidal activities.
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| Author:
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ASWINI RANGAYASAMI, KARTHIK KANNAN, MURUGESAN SUBBAN
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| Abstract:
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The present study of L. revoluta bulb extract have various phytocompounds reveals the imminence of alkaloids, flavonoids, saponins, tannins, sugars oils and resins. Further introduces of phytochemicals were recognized by thin layer chromatography (TLC). The GC-MS analysis indicate having nearly 30 major compounds are presented in the methanol extracts of Ledebouria revoluta bulb, in chloroform extract found 17 compounds and in ethyl acetate extract had 14 compounds. Presenting compounds are involved in different biological activity like antibacterial, antioxidant, anticancer etc. Antibacterial activity was determined by well diffusion assay and methanol extract showed the maximum inhibition in all bacteria at highest zone of inhibition at C. tetani (9.6 ± 1.52 (60µl)). The antioxidant properties of the chloroform, ethyl acetate and methanol extract was determined by DPPH and ABTS radical scavenging assay. The methanol (IC50 value of 92.61 µg/ml) extract showed the better radical scavenging activity than other selected solvents. Anticancer activity of the extract was evaluated against A549 cell line. The larvicidal movement of three selected solvent extract was studied on third instar larvae of Aedes aegypti. The result strongly suggests that extracts of methanol revealed the potential to antibacterial, antioxidant, anticancer activity in addition to larvicidal activity against Aedes aegypti.
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| Keyword:
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Anticancer, Antioxidant, Antibacterial, GC-MS, TLC analysis, Larvicidal activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.165
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| Download:
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