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A novel approach for spectrophotometric determination of naproxen
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| Author:
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DR.HANA SH.MAHMOOD, THURA Z. FATIH-ALLA
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| Abstract:
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In the present pandemic , Naproxen is one of the important drugs in which it blocks the binding groove of RNA nucleoprotein of influenza virus, in this paper (S)-2-(6-methooxynaphthalen-2-yl)-(+) propionic acid (Naproxen) has been refluxed with hydrobromic acid and acetic acid to form (S)-2-(6-hydroxynaphthalen-2-yl)-(+) propoinic acid (the hydroxyl analog of Naproxen , HAN). HAN has been oxidized with iron (III) ion followed by complex-formation reaction with 2,2-bipyridyl at 35°C in acidic medium to form an orange-red, complex that is soluble in water with good stability and exhibits maximum absorption at 523 nm. Concentration linearity range was from 0.25 to10 µg/ml of HAN. The calculated molar absorptivity is 6.0×104 l/mol.cm, Sandell’s index for sensitivity is 0.0260 µg/cm2, relative error % is from -0.1 to 0.15,and the rang of relative standard deviation % is from ± 0.10 to ± 0.35 % depending on the concentration level. 0.0132µg/ml is the limit of detection (LOD) and 0.0442 µg/ml is the limit of quantitation (LOQ). Nap has been determined in pure form. The application to the Naproxen Tablets requires an extraction by ethyl acetate in acidic medium.
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| Keyword:
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Naproxen, influenza, spectrophotometric, reflux, 2,2-bipyridyl, extraction
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.162
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| Download:
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