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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of New Asymmetric Double Schiff Bases Containing a New 5-Bromosalicylaldehyde Aniline - Chitosan Derivative

Author: R.IDA MALARSELVI, A. DEEPIKA, C. RAMACHANDRA RAJA, R. PRISCILLA
Abstract: Chitosan is a well-known compound with strong anti-microbial activity. The chitin and phenyl rings deviate from co-planarity with an inter and intra-molecular (–C2-N=CH–) and (–C6–C=N–) imine bonds. The title compound C69H118BrN10O41 is not a planner, with a dihedral angle among the planes of the three aryl rings. To create more potent anticancer agents, a novel chitosan derivative have been obtained by simultaneous modification at C6 (Amino group) and C2 (Carbonyl group) positions and characterized by FT-IR, 1H-NMR, 13C-NMR, GC-Mass spectroscopy, and thermal analysis. The structure is a heterocyclic derivative constituting a stimulating class of compounds with synthetic flexibility and effective biological activities.
Keyword: Asymmetric scaffold, Activation energy, Vibrational, NMR spectra and Thermal analysis.
DOI: https://doi.org/10.31838/ijpr/2020.SP2.135
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