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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and characterization of the atenolol-ßcyclodextrin-poloxamer 188 ternary inclusion complex with solvent evaporation method

Author: KARINA CITRA RANI, AGNES NUNIEK WINANTARI, MUHAMMAD HABIBUR ROHMAN, STEPHANIE
Abstract: Purpose: The aim of this study was to develop a ternary inclusion complex of atenolol-ß-cyclodextrinpoloxamer 188 to enhance the dissolution of atenolol. Methodology:The ternary inclusion complex of atenolol-ß-cyclodextrin-poloxamer 188 in this study was developed into three different ratios (1:1:0.00075; 1:1:0.00015; 1:1:0.00225). The solvent evaporation method was employed to produce these inclusion complexes. The inclusion complexes were characterized using FT-IR, DSC, XRD and SEM. The obtained inclusion complexes were also evaluated to determine the drug content and dissolution parameters. Results: The results of FT-IR analysis exhibited interaction of atenolol, ß-cyclodextrin, and poloxamer 188 through hydrogen bonding in the inclusion complex. Results of DSC and XRD study suggested the conversion of atenolol from a crystalline form to amorphous form. SEM analysis of inclusion complexes revealed that atenolol was entrapped in the ß-cyclodextrin cavities and poloxamer 188 attached on the surface of ßcyclodextrin.The dissolution profile of these inclusion complexes showed enhancement of atenolol dissolution compare to pure atenolol. The inclusion complex using 1:1:0,00015 ratio performed the highest dissolution efficiency among three ratios. Therewere a 1.2 fold increases in dissolution efficiency of inclusion complexes compared to the pure drug. Applications/Originality/Value: In ternary inclusion complex, ß-cyclodextrin served as a versatile carrier to entrap the drug inside their cavity via hydrogen bound interaction. The addition of poloxamer 188 is also required to enhance aqueous solubility and fasten the rate of dissolution of atenolol. There was no study to develop a ternary inclusion complex of atenolol using ß-cyclodextrin and poloxamer 188.
Keyword: atenolol; ß-cyclodextrin; ternary inclusion complex; solvent evaporation
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