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Direct and new flow injection method for assay of Iron as ferrous sulfate in pure and dosage forms through the complexation with 2,2? dipyridyl reagent
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| Author:
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LUMA L.HAMED, BUSHRA B. QASSIM
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| Abstract:
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The proposed method describes fast, simple, economical, responsive and highly accurate method for determining of ferrous ions using batch and CFIA/ merging zones techniques. The method was based on a direct reaction of Ferrous ions with 2,2? dipyridyl agent to form a pink-red complex which has a strong absorption at 522 nm using distilled water as carrier stream. The reaction being stoichiometric with a 1:3 ratio (M: L) via Job’s and molar ratio methods. The suggested technique was permit for determination of Fe (II) in pure material and pharmaceutics products with linear range (3-30) µg.mL-1 and (8-100) µg.mL-1 for batch and CFIA / merging zone methods, respectively. Verified sample throughput of 54 h-1. The proposed method was applied successfully for estimation of ferrous sulfate in multi-vitamin tablets with high selective and sensitive of the obtained results gained are favorably compared with those given by a reference method presented in the pharmacopoeia.
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| Keyword:
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Ferrous sulfate, CFIA/Merging Zones, 2,2? dipyridyl, Spectrophotometric detection, Dosage forms.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.128
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| Download:
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