|
Single Nucleotide Polymorphism of IL-10 gene rs3024491 in a Sample of Rheumatoid Arthritis Iraqi Patients
|
|
| Author:
|
ASEEL S.MAHMOOD, ABDUL-KAREEM A. AL-KAZAZ, ALI H. AD'HIAH
|
| Abstract:
|
Cytokines play a prominent role in etiology and pathogenesis of rheumatoid arthritis (RA), and one of these cytokines is interleukin-10. The association between IL10 gene single nucleotide polymorphism (SNP: rs3024491) and rheumatoid arthritis (RA) in a sample of Iraqi patients was investigated. Fifty-one RA patients (21 males and 30 females) were enrolled and their age range was 20 - 63 years (44.9 ± 1.5 years). In addition to patients, 45 apparently healthy control subjects were also enrolled in the study. They matched patients for ethnicity (Iraqis), gender (14 males and 31 females) and age (41.3 ± 1.3 years). Analysis of Hardy-Weinberg equilibrium (HWE) in RA patients and controls revealed that the IL10 genotypes were consistent with the equilibrium, and no significant differences (p > 0.05) were observed between the observed and expected genotype frequencies. Inspecting IL10 genotype and the allele A frequency was significantly decreased (30.4vs. 43.3; p = 0.044; OR = 0.57; 95% C.I.: 0.32 - 1.03; EF = 0.19).. In conclusion, the results are in favor of no association between IL10 gene SNP (rs3024491) and RA in Iraqi population.
|
| Keyword:
|
Cytokines, HWE
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP2.147
|
| Download:
|
Request For Article
|
|
|