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Fabrication And Evaluation Of Self-Emulsifying Drug Delivery System (SEDDS) Of Antiretroviral Drug For Treatment Of HIV
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| Author:
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HEMANT A.DEOKULE, SMITA S. PIMPLE, KIRAN C. MAHAJAN
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| Abstract:
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The present study aims are to develop and optimize self-emulsifying drug delivery systems (SEDDS) for pediatric and geriatric drug delivery to improve the oral bioavailability of antiretroviral drug Dolutegravir Sodium BCS Class II molecule and to perform its in vitro dissolution study. Dolutegravir Sodium is also a substrate for p-glycoprotein (p-GP), which efflux the molecule into the intestinal lumen and hence decreases the oral bioavailability. The solubility of Dolutegravir Sodium was estimated in various vehicles to select proper component combination. The SEDDS formulation consisted of Dolutegravir Sodium, Capmul MCM (oil), Tween 80 (Surfactant), and Propylene glycol (co-surfactants). The pseudo-ternary phase diagram was constructed to identify the self-emulsifying regions. Fifteen formulations composed of Capmul MCM, at Smix ratios (1:1, 2:1 or 3:1) were selected. They were spherical in the shape of mean globule size 57.7nm with negative zeta potential -69.6-mV with emulsification time 22 sec. The in vitro release profile of Dolutegravir Sodium-SEDDS was found significant. The results indicate that Dolutegravir Sodium loaded SEDDS with enhanced solubilization and nanosizing, has the potential to improve the absorption of the drug.
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| Keyword:
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Dolutegravir Sodium, Self emulsifying drug delivery system (SEDDS), Solubility, Ternary phase diagram.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.132
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| Download:
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