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Optimization and Characterization of Gellan Gum Based Ocular In Situ Combigel Formulation of Gatifloxacin and Ketorolac
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| Author:
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ANKITA KAPOOR, GHANSHYAM DAS GUPTA
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| Abstract:
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The present research work explains formulating, refining and testing an in-situ combigel ion-activated ocular formulation. It consists of gatifloxacin and ketorolac for bacterial conjunctivitis to resolve patient pain, replacement of precorneal medications, improvement in effectiveness, distorted vision and frequently instilled eye drops and ointments. Gellan gum as an ion-enabled phase transition polymer was developed and HPMC K100 M as release retardant. Instant gel forming in simulated lacrimal fluid was demonstrated (pH 7.4), and its rheology, inflammation, in vitro release, trans cord permeation, and antimicrobial activity were further evaluated. In the formulation with the viscosity 55 cps in sol form and 330 cps with a pseudo plastic action with a consistency of 216.50gm.sec, power 28.320gm, viscosity indices 37.425gm.sec and cohesiveness 17.782gm, 0.6% gellanic gum and 0,4% HPMC K100 M is optimised. The formulations produced demonstrated a persistent and long in-vitro release and permeation profile in 80.1 percent of gatifloxacin and 89.7 percent of ketorolac in 8 hours, with a non-irritant score of 13.21. Due to its higher inhibition environment, its ability to improve residence time and subsequently ocular bioavailability with lower administration rates due to sluggish, protracted diffusion of the medication from the polymer solutions, this formulation is an effective medicine.
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| Keyword:
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Gatifloxacin, Ketorolac, In-situ, Pseudo Plastic, Non Irritant, Isotonic, Rheology, Ion Activated.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.119
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| Download:
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