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The Role of Matrix Metalloproteinases in Wound Healing
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| Author:
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S.GANESH , K.R.DON, JOTHI PRIYA.A
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| Abstract:
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Matrix metalloproteinases (MMPs) are key effector molecules responsible for extracellular matrix (ECM) turnover. They are involved in tissue remodeling and regeneration. Although the main targets for MMPs are ECM components, they are also able to digest a variety of non-ECM molecules including cytokines, their receptors, or carriers. Therefore, the activity of the MMPs remains under tight control. However, when controlling mechanisms are ineffective, MMPs may become highly dangerous molecules, which have a strong destructive effect on affected tissues.The timed expression and activation of MMPs in response to wounding are vital for successful wound healing. MMPs are grouped into eight families and display extensive homology within these families. This homology leads in part to the initial failure of MMP inhibitors in clinical trials and the development of alternative methods for modulating the MMP activity. Apart from cancer metastasis, aneurysm formation, or airway remodeling in asthma, MMPs have also been identified as main detrimental factors in delayed healing of chronic wounds.Wound healing is a complex process which involves a coordinated response of many cells and is fundamentally similar among tissue types. Among the many gene products that are essential for restoration normal tissue architecture several members of matrix metalloproteinase ( MMP ) function as positive and negative regulation of the repair process. Wound healing requires the controlled activity of MMPs at all stages of the wound healing process. The loss of MMP regulation is a characteristic of chronic wounds and contributes to the failure to heal. In this review we discuss MMPs in wound healing and it will provide better treatment of wounds.
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| Keyword:
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Matrix metalloproteinase, Extracellular Matrix, wound healing, tissue remodeling.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.087
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| Download:
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