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Assessment of extracellular matrix condition in persons with undifferentiated connective tissue dysplasia
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| Author:
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SHODIKULOVA GULANDOM ZIKRIYAEVNA, BABAMURADOVA ZARRINA BAKHTIYAROVNA, MIRZAEV OZOD VOHIDOVICH
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| Abstract:
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Objective: to carry out comparative analysis of matrix metalloproteinase’s-2,9 (MMP-2, 9), tissue inhibitors of matrix metalloproteinase’s (TIMP) expression indexes and their interconnection with magnesium ions (Mg2+), glucosamine-glycans and glucuronidases activity in the blood of patients with undifferentiated connective tissue dysplasia. Material and research methods. 208 persons of them aged 15-25 (19.9±1.42) years have been studied. Depending on clinical signs and progressive complications, patients were divided into 2 groups, 1-group 97 patients with signs of external phenotypes (fens) of UCTD, 2-group 111 patients with signs of external and internal fens, with some complications. Results of researches have shown that the blood of patients with UCTD showed an increase in MMP-2 and MMP-9 and a decrease in TIMP-1. As the progression of the disease increases, the expression of MMP-2 and MMP-9 increases and the TIMP-1 decreases, compared to the data in the control group. At the same time, in patients there is a decrease in Mg2 ions in blood. Thus, dynamics of changes of MMP-2 and MMP-9 and also TIMP-1 expression in patients with undifferentiated connective tissue dysplasia may serve as a method of estimation of progressive pathological process and prognosis of the disease.
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| Keyword:
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undifferentiated connective tissue dysplasia, matrix metalloproteinase’s, inhibitors of matrix metalloproteinase’s, magnesium (Mg2+) ions.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.265
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| Download:
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