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Derivative Spectrophotometric Determination Of Ibuprofen In Pure Form And Pharmaceutical Preparation
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| Author:
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MARWAH S.YONES
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| Abstract:
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Derivative spectrophotometric (first and second derivative) were used for the determination of ibuprofen for pure synthetic. Also, determination of ibuprofen in (ibuprofen 200 mg) tablet was applied. IBU was determined by using 1D and 2D methods at 228.6 and 225.6 nm with linear concentration range 2-30µg.mL-1, with correlation coefficient r (0.9971, 0.9980) relative error (-4.2, -0.92) respectively. No interference found between both determined and those of matrices. A good accuracy and precision of determination of IBU was confirmed by statistical analysis. The percentage recovery of the individual drugs under the established conditions is ranged from 95.8% to 99.08%, the proposed procedures were successfully applied to the determination of these compounds in different ratio by synthetic and pharmaceutical tablet without requiring any separation step.
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| Keyword:
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Ibuprofen; Derivative spectrophotometry; Zero crossing.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.051
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| Download:
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