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Molecular and Immunological Mechanisms of Channa striata in Diabetic Wound Healing
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| Author:
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INDRA WIJAYA, NURPUDJI A.TASLIM, ROSDIANA NATZIR, I MAKBUL AMAN, MOCHAMMAD HATTA, BUDHI SUHUDI, I ASADUL ISLAM, MUHAMMAD NASRUM MASSI, ILHAMJAYA PATELLONGI, I M.ICHSAN
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| Abstract:
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The prevalence of Diabetes Mellitus is increasing globally, approximately 463 million people in the year 2019, and is predicted to 700 million people by the year 2045, and it has high comorbidity and mortality based on International Diabetes Federation (IDF). The wound healing process can be divided into 4 phases, which are homeostasis, inflammatory, proliferation, and remodeling phase. Each phase plays a major important role and has an interconnecting signal network to complete the process. The hyperglycaemic condition has been known to have an impact on inhibiting vascular homeostasis, elevating oxidative stress, elevating procoagulant-proinflammatory cytokines, and inhibiting angiogenesis, therefore delaying the wound healing process. Diabetic wound healing is somehow made it very challenging. Various traditional medicine has been studied to have a pivotal role in enhancing immunological response at the molecular level. Channa striata (snakehead fish) has a potential role in regulating molecular and immunological mechanisms since it has been known to have an impact in accelerating the wound healing process, due to its antiinflammation, antioxidant, and promote cell proliferation and tissue remodeling. Several studies have revealed its molecular and immunological mechanisms, such as enhancing regulatory T-cell, inhibiting CD68+, inhibiting TNF-a, IFN-?, IL-6, NF-?B, and increasing SDF-1a chemokines. The objective of this article is to review comprehensively the molecular and immunological mechanism of Channa striata in the diabetic wound healing process.
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| Keyword:
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Channa striata, diabetic wound healing, molecular, immunology
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.046
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| Download:
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