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Cytopathic And Nuclear Changes Of Oral Mucosa In Non Habit Oral Cancer Patients With Concurrent Irritation Of Oral Mucosa
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| Author:
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MEENAPRIYA M, DR.GHEENA.S
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| Abstract:
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Oral cancer is one of the 6th most common cancers in the world and globally more than 50% of the head and neck cancers occur in Asia, remarkably in India. In India, according to the current epidemiology statistics (2018), the age standardized ratio of incidence of lip, oral cavity cancers is 9.1. Long standing irritations or Chronic mucosal trauma have been postulated as the risk factor for developing oral cancer. Chronic irritation of the oral mucosa may result due to the poor oral hygiene, poor dentition, missing teeth or sharp teeth. Even in the absence of clinical changes of the oral mucosa, the cytopathic and nuclear changes can be detected through the exfoliative cytology. This study aims at assessing the cytopathic and nuclear changes of oral mucosa in patients with non habit oral cancer at the contralateral site of malignancy. A pilot study was conducted among the patients with non habit oral cancer with concurrent irritation of oral mucosa in 2018. The study group included 25 patients, the cases of oral cancer which included squamous cell carcinoma, verrucous carcinoma and others which were confirmed histopathologically. They were questioned on their dietary habits, occupation, stress, medical and dental history, ulceration history and so on. The patients were also enquired about their negligence towards any lesion because of the chronic mucosal trauma. The data were collected and tabulated. The results were statistically analysed using SPSS and Pearson’s chi-square test was performed. A total of 115 oral cancer patients were recorded in the hospital during the period of January to December 2018. Among these 25 patients did not have any habits. Out of these 25 patients, 9 (36%) were females and 16 (64%) were males. The mean age group was 53 years. The study group revealed that 90% of the patients were unemployed. Their dietary habits were normal. The study group showed that the following oral cancers were found which were just noted as Oral carcinoma (20%), squamous cell carcinoma (64%), verrucous carcinoma [8%] and verrucous carcinoma turning into squamous cell carcinoma (8%). Regarding the location, tongue (48%), buccal mucosa (24%), mucosa adjacent to the tooth region (28%), tonsillar papillae (4%) were involved. Chronic irritation of the oral mucosa acts as a cofactor in oral malignancies. Proper treatment of the mechanical injuring factors could reduce the risk of oral cancer. Thus more epidemiological and clinical studies that concentrate on chronic irritation of oral mucosa and onset of oral cancers are needed.
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| Keyword:
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Oral cancer, non habits, mucosal trauma, squamous cell carcinoma, sites.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.015
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| Download:
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