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Epileptogenic Drugs and Seizures: A Comprehensive Review of Current Knowledge
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| Author:
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AMAN SHRIVASTAVA, MANOJ KUMAR GOYAL, JEETENDRA KUMAR GUPTA
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| Abstract:
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Epilepsy is the neurological disorders in which several behavioral changes occur due to excessive electrical discharges on group of neurons in the brain. Epilepsy occurs in the hippocampus region of the brain. Some neurotransmitter like GABA and Glutamate play the important role for causing epilepsy. This review aimed to develop better understanding about epileptogenic drugs and some other aspects. A few clinical studies have reported that vitamin D can be helpful for controlling the effect of seizure and also act as a neuroprotective agent. It is well known that antiepileptic drugs are generally used for the treatment of epilepsy or related symptoms. In Pathogenesis of epilepsy, the concept developed for epileptogenesis comprises activities affecting both the origin and occurrence of epilepsy. GABA is known as the primary inhibitory neurotransmitter, inducing presynaptic inhibitory activities by hyperpolarizing the neuron. In this article, we have classified the epileptogenic drugs with their potential ability for increasing the risk of epileptic seizure. Epileptogenic drugs can also cause inflammation in brain. There are various inflammatory mediators released by taking the overdoses of some epileptogenic drugs. In this review, we also discuss toxicity study of common anti-epileptic drugs include idiosyncratic effect, local effect and effect on fetus during pregnancy period and common other neurological disorder induced by the use of epileptogenic drugs.
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| Keyword:
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Epileptogenic, Pathogenesis, Neurotransmitter, Causes, Toxicity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.011
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| Download:
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