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Improving Prochlorperazine Profile by Formulating the Drug as Nanoemulsion Delivery System
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| Author:
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MARYAM ALAAYEDI, ASHTI SAEED, HASANAIN SHAKIR MAHMOOD
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| Abstract:
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Nanoemulsion is one of the recent promising field for research which depends on the attractive components characteristics to enhance oral drug delivery including prochloperazine (PCP) that is utilized for the management of nausea and vomiting. PCP exhibits low aqueous solubility, low absorption and low bioavailability. For these reasons, this study aims was to produce stable PCP nanoemulsions which could enhance the lipophilic PCP solubility, then its bioavailability. The solubility of PCP was determined using different vehicles to choose the optimum solubilizer for the drug in order to select the appropriate oil, surfactant and co-surfactant based on controlling HLB (hydrophilic/lipophilic balance) more than 10 to produce w/o nanoemulsion. The formulas of nanoemulsion were produced using different amount of peppermint oil, tween 80 (surfactant) and transcutol HP (co-surfactant) using titration method against water at different surfactant/co-surfactant ratios of 1:1, 2:1, 3:1, and 4:1. The produced nanoemulsion were evaluated for many tests including stability studies, droplet size and distribution, zeta potential, polydispersity index, spreadability, miscibility pH, viscosity, electroconductivity, transmittance, transmittance, scanning electron microscopy (SEM), surface tension and drug dissolution. The results found that the extant and rate of PCP release for the all formulas were significantly higher than the pure drug powder and the available marketed tablet. It is demonstrated that nanoemulsion is a promising strategy for improving PCP bioavailability as shown in the dissolution, the optimized formula released all its drug content in less than 1 hour and the pure powder exceed 2 hours and not yet released an acceptable amount of drug.
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| Keyword:
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Bioavailability, solubility, prochloperazine, nanoemulsion.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.394
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| Download:
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