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Monitoring The Side Effects Of Psychotropic Drugs Prescribed In Tertiary Care Hospital
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| Author:
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MR.MANYAM MEGHANADH, MR. RAKSHITH K, MR. KOUSTUV RAY CHOUDHURI, DR. N M MAHESH, DR. VEDA SHETAGERI, MR. VINOD. K. MATHEW
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| Abstract:
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Objectives: To monitor the side effects of psychotropic drugs prescribed in a tertiary care hospital.
Methodology: A descriptive-observational study was carried out in the psychiatry department of MVJ medical college and research hospital for six months from October 2017 to March 2018. A total of 107 in-patients were enrolled into the study after fulfilling the study criteria and obtaining informed consent. Causality was assessed using WHO UMC scale and UKU scoring were done to assess the side effects. The baseline side effects score was recorded and the subsequent data were collected at the end of each week, for three weeks consecutively. The obtained data were analyzed statistically and descriptively.
Results: A total of 107 patients were enrolled into the study of which majority of the patients were females (54%). Most of the patients belong to the age group of 28-37 years (47.6%). 93% of our sample population was married. Schizophrenia was found to be the most common psychotic disorder with prevalence 26.7%. On analyzing the prescription, most of the patients were treated with two psychotropic agents (58%), of which antidepressants + benzodiazepines combination was more frequently used (33%), followed by an antidepressant monotherapy (13%). Our study also revealed, there were a total of 33 drug-drug interactions found out of which 22 were major. The side effects found were grouped into four classes - psychic, neurologic, autonomic and others, as per the UKU scale. Majority of the patients experienced side effects under psychic class (82%). The side effects were found to be statistically significant with **P-value <0.0001 (CI=95%) using logistic bivariate fit analysis.
Conclusion: Our study showed that dry mouth, sedation, headache, weight gain, and constipation are the most common yet serious side effects of antipsychotics. Among these, weight gain is one of the predominant side effects in our study and second-generation antipsychotics are the offending agents. The side effects associated with antipsychotics are confounded by various factors like drug-drug interactions and polypharmacy.
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| Keyword:
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Side effects, Psychotropic Drugs, Antidepressants, Mood stabilizers.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.366
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| Download:
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