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What to Choose among Amlodipine or Cilnidipine in Hypertension?
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| Author:
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SAI ARAVIND DANGETI, A. SRAVANI, P. DEEPTHI, S. BALA BHAVANI, DR. P. N. S. HARITHA, SATHEESH S. GOTTIPATI
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| Abstract:
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Aim: Hypertension, or high blood pressure, is a very common and serious condition that can lead to or complicate many health problems. CCBs play an important role in controlling the blood pressure. Both Amlodipine and Cilnidipine are drugs of choice. We undertook the present study to compare Amlodipine and Cilnidipine on Antihypertensive efficacy and their effect of the drug on heart rate in hypertensive individuals. The present study included 119 subjects out of those 64 subjects were on cilnidipine and 55 subjects were on amlodipine. Auscultatory method with standard mercury sphygmomanometer was used for the measurement of the blood pressure. Three reading were taken after three months of the treatment and mean of highest two reading of blood pressure was considered for the study. The heart was measured at the same time.
Results: The mean SBP in the Amlodipine group subjects and in the Cilnidipine group subjects was 132.7 and 145.86 mmHg respectively. The mean DBP in the Amlodipine group subjects and in the Cilnidipine group subjects was 82.73 and 84.30 mm of mercury respectively. There is more significant decrease in the systolic blood pressure in the patients using amlodipine than in the patients using Cilnidipine with a probability of 0.001 and there is no significant decrease in the diastolic blood pressure in two groups. There is an increased heart rate in the patients who are taking amlodipine with a probability of 0.035 when compared to Cilnidipine.
Conclusion: In our study Amlodipine had shown more efficacy than Cilnidipine. Amlodipine had also shown reflex tachycardia. Depending on the risk to benefit ratio we conclude that Cilnidipine drug of choice than Amlodipine to prescribe for the patients with diagnosed with hypertension.
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| Keyword:
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Hypertension, Calcium channel blockers, Heart rate, Pedal edema.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.365
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| Download:
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