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Histopathological and Physiological Study of Drug Related Hyperostosis in rat
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| Author:
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BATOOL S.HAMZA, ZAINAB W. KHUDAIR, ISHRAQ J. HASAN
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| Abstract:
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Hyperostosis is a condition in which there is enlargement of the outer portion of bones. However, a range of conditions in which there is thickening of the endosteal surface can also occur. The present study aims to evaluate the histopathological changes induction hyperostosis by doxorubicin on femur & joint. The experiment was done on 80 male & female rats (Rattus norvegicus) sexually mature weighing 150-200 gram, divided into 4 equal groups of 20 animals each: control group which was given distilled water while the treated animals injected with drug (doxorubicin) I/P as dose 2.5 mg/ Kg, 5 mg / Kg, & 10 mg / Kg represented low toxic dose, intermediate toxic dose, finally high toxic dose respectively for sex month.
The animals scarified after six months then the femur and joint taken to prepared histopathological slides and examined to observe the pathological changes that induction by drug. The present aimed to study pathophysiological changes of doxorubicin on the bone tissues of femur and joint in the rats.
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| Keyword:
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hyperostosis, drug, doxorubicin, femur, rats
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.346
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| Download:
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