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“Nephro-Protective Activity of Berry Powder of “Hippophae Rhamnoides” Against Cisplatin Induced Nephrotoxicity”
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| Author:
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SPANDANA UPPULURI, K.SOWJANYA, V.VAISHNAVI, J.KUNDANA BHAVANI, M.JENNIFER, K.STEFI SELES
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| Abstract:
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Objective: To investigate and report the nephro-protective role of the berries of “Hippophae rhamnoides”(berry powder of Sea Buckthorn) against cisplatin induced nephrotoxicity in albino wistar rats.
Methods: In the present study, the extract of berries about 200 mg & 400 mg/kg b.w was examined for its nephron-protective effect against cisplatin induced renal injury in rats. Thirty six healthy male and female albino rats (150–200 g weight) were choosen and divided into six groups. The experiment was conducted for 10 days, after treatment time , the urine and blood samples were collected for analysis of nephroprotective activity. For the analysis Urine, blood parameters were analysed. The urine parameters are UTP, creatinine clearance. Blood parameters are serum creatinine, BUN. Histopathological characters were examined after scarifying and dissecting the kidneys of albino rats.
Results: Cisplatin (6mg/kg) significantly elevated the level of serum markers, urinary protein excretion and is also used for reduction in urine to serum creatinine ratio and creatinine clearance alone.In curative regimen, the extract significantly reduced the elevated serum creatinine and urea levels. Renal antioxidant defense systems, such as catalase,glutathione, peroxide activities and reduced glutathione level, depleted by cisplatin therapy were restored to normal by treatment with the berry extract.
Conclusion:On evaluating biochemical parameters like UTP, BUN, creatinine clearance, serum creatinine it was found that the berry extract of “Hippophae rhamnoides” showed nephro-protective activity in cisplatin induced nephrotoxicity.
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| Keyword:
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: Cisplatin, Hippophae rhamnoides, nephrotoxicity, nephro-protective activity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.324
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| Download:
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