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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Prevalence Of Metabolic Syndrome And It’s Complications Among Patients With Rheumatoid Arthritis

Author: SHUMOOS H ALWAID, MARYAM KADHIM AL-SHEMERY, RUSUL ALI AL-MASAOODI
Abstract: Rheumatoid arthritis (RA ) is a chronic systemic inflammatory autoimmune condition characterized by weight loss, weakness, malaise, and anaemia by the articular and extra-articular manifestations. The aimed of this study was to determine the prevalence of metabolic syndrome in its association with disease severity among patients with RA in the province of Al-Najaf / Iraq and the related risk factors. This study, which included 75 subjects, included 50 patients with rheumatoid arthritis and 25 subjects were healthy. patients and control subjects were assessed the liver function test, kidney function test, lipid profile and some electrolyte assessment . The outcome of this study indicates a significant increase (p<0.05) in glucose and ALP relative to control in patients with arthritis. There is also statistically no significant difference in HDL and an increase (p<0.05) in Cholesterol and Tg serum levels in patients with arthritis relative to controls . At the same time, the findings suggest that a significant (P<0.05) decrease in the mean potassium level whereas substantial (P<0.05) increases the mean sodium level in arthritis patients as opposed to control subjects . In our research, we concluded that in rheumatoid arthritis patients, the elevated level of Tg and ALP is corelated with the baseline prevalence of metabolic syndrome . The findings of this analysis also support the hypothesis that rheumatoid is lowring serum potassium level.
Keyword: Rheumatoid arthritis, Metabolic syndrome ,Glucose, ALP, and electrolyte
DOI: https://doi.org/10.31838/ijpr/2020.SP1.317
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