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Serum glycogen phosphorylase BB (GPBB) level and Prolidase activity as markers in diagnosis of ischemic stroke
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| Author:
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MARYAM EMAD SHAKER, DR. ZEENA ABDUL LLAH
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| Abstract:
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Objective: We aimed to investigate whether Serum Prolidase Activity (SPA) levels and plasma levels of glycogen phosphorylase BB (GPBB) isoform could be used as apotential diagnostic biomarker in Acute Ischemic Stroke (AIS) patients or not.
Materials and methods: SPA levels showed no significant evaluation in 40 patients and glycogen phosphorylase BBwere prospectively evaluated in 40 patients aged between 40to70 ywho were admitted within 24 h of the onset of AIS. The control group included 40 healthy volunteers of similar age without any disease.
Results:There is a significant elevation in the level of GPBB in ischemic strokegroup and compared with control group. For Control, the observations of GPBB had an Min = 1.27.For Stroke, the observations of GPBB had an Min = 1.3837
There was a significant positive correlation between stoke and Glycogen phosphorylase (rpb = 0.7473, p< .001). The correlation coefficient between Stroke and Glycogen phosphorylase was 0.7473 indicating a large effect size. This indicates that moving from the Not having to having Stroke is associated with an increase in Glycogen phosphorylase. Therefore, Stroke tends to be associated with higher values of Glycogen phosphorylase
There was small effect size correlation between Stroke and Prolidase (rpb = -0.1396, p0.2177).As the computed p-value is greater than the significance level alpha=0.05. Prolidase is not associated with stoke.
Conclusions:
1. This study shows there is significant elevation in enzyme level ofglycogen phosphorylase BB (GPBB) in ischemic strokegroup and compared with control group.
2. This study shows There was small effect size correlation between Stroke and Prolidase ,Prolidase is not associated with stroke.
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| Keyword:
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Prolidase, Serum glycogen phosphorylase BB ,GPBB, ischemic stroke, Serum Prolidase Activity (SPA)
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.316
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| Download:
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