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Evaluation of antiarthritic activity of aceclofenac amphiphilogels against Freund’s complete adjuvant induced arthritis in rats
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| Author:
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HIMANI BAJAJ, VINOD SINGH, RANJIT SINGH, TIRATH KUMAR
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| Abstract:
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The surfactant-based amphiphilogels were developed by means of different surfactant combinations, such as Span 60, Tween 80 and Tween 20. Optimized formulations were further selected and evaluated for their stability, acute skin irritation studies and in-vivo anti-arthritic activity using primary skin irritation (draize) test and Freund's Complete Adjuvant (FCA) induced arthritis method. The stability study for the transdermal amphiphilogels formulation was done as per ICH guidelines. The tested formulations were devoid of any irritation potential and no edema formation was observed in any case. Irritation score (primary skin irritation index) for all the formulations was found to be zero, which indicated its safety and acceptability for transdermal administration. Formulation F2 and A3 were selected for the in-vivo study which revealed a significant reduction in inflamed paw volume compared to the marketed formulation. The developed amphiphilogels could be a potential drug delivery platform for the management of arthritis.
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| Keyword:
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Aceclofenac, Amphiphilogel, Arthritis, Surfactants, Transdermal.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.260
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| Download:
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