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Physiological Dysfunctional Effects of Levetiracetam in Rats
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| Author:
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WISSAM SAJID HASHIM, AIAD GABER AREAN
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| Abstract:
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Objective: The aim of performing this study was to reveal the anticipated effects of levetiracetam on lipid profile, hepatic and renal functions.
Materials and Methods: Twenty four adult male rats of 180-200 grams weight were adopted. Rats were randomly allocated into three groups; Control, Levetiracetam 250mg, and Levetiracetam 500mg. The experiment period was one month. The control group rats were dosed with distilled water. Levetiracetam 250mg were orally dosed with 250 mg levetiracetam and the Levetiracetam 500mg group were orally dosed with Levetiracetam 500mg. All groups were dosed daily for one month.
Results: The results revealed that levetiracetam causes significant elevations in triglycerides, low density lipoprotein, total cholesterol, very low density lipoprotein, hepatic aminotransferases, alkaline phosphatase, renal urea and creatine with significant decrease in high density lipoprotein comparing among the treatment groups and with the control at (P=0.05).
Conclusions: Levetiracetam does effect the rats lipid profile, hepatic and renal function.
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| Keyword:
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Levetiracetam, Keppra, AED, Liver, Kidney, Rat.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.279
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| Download:
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