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Synthesis and Antimicrobial Activity of 2-(4-Oxo-2-Phenyl Quinazolin-3(4H)-Yl) Propane Hydrazide Derivatives
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| Author:
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KADHUM JWAD K., AUSAMA ABED ALKADHUM ALAJEELY, FADHEL OMRAN ESSA
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| Abstract:
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In the present study,some new2-(4-oxo-2- phenylquinazoline derivatives have been prepared starting from reaction of the latter with alanine yielded 2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanoic acid (1). The reaction of compound (1) with thionyl chloride produced 2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanoyl chloride (2). Condensation of compound (2) with hydrazine hydrate afforded 2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanehydrazide (3).The azomethines (4a-d)were synthesized from the reaction between corresponding aldehydes and acid hydrazied(3). Treatment of Schiff base with glycine resulted in the new N-(5-oxo-2-phenylimidazolidin-1-yl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl) propanamide (5a-d).
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| Keyword:
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Phenyl quinazoline, Alanine, Hydrazide, 1,2-Dihydropyridazine, Azomethines. Antibacterial activity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.227
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| Download:
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