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Development and Evaluation of Nanoparticles Loaded Topical Gel for the Treatment of Psoriasis and Other Skin Conditions
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| Author:
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SURYAKUMARI CHALAKANTI, NARENDER MALOTHU, UMASANKAR KULAINDAIVELU, SIVA PRASAD PANDA, KOTESWARA RAO GSNK
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| Abstract:
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In the present study, lipid nanoparticles mainly Nanostructured Lipid Carriers (NLCs) based topical gels of Tacrolimus was papered for transdermal delivery for treatment of psoriasis and other skin conditions. Nanostructured lipid carriers (NLC) are composed of binary mixture of solid lipid and a spatially different liquid lipid as the carrier. The major advantage of NLC is increased drug load. Stearic acid as the solid lipid, oleic acid as the liquid lipid, and Tween 80 as the surfactant, and Poloxamer as the co-surfactant were used. NLCs were prepared by high-speed hot homogenization methods. The gels were tested for particle size analysis, entrapment efficiency, zeta potential and, viscosity, surface pH, drug content, FTIR, studies showed no evidence on interactions between drugs, polymers and excipients. , DSC, XRD, SEM, Loading capacity, in vitro drug diffusion study, skin irritation study, analysis of permeation data and anti-inflammatory study using exvivo permeation study using rat abdominal skin, Tacrolimus- NLCs was successfully demonstrated by this method. In vivo release, and then they were incorporated in a carbopol hydro gel to determine the influence on the In vitro drug transdermal delivery. In this study NLCs of Tacrolimus with the particle size 123.8 nm was formulated, which showed entrapment efficiency of 91.3±12 and zeta potential -31.1 Mv. The results revealed that there is increased solubility and bioavailability of the NLCs as anti-psoriasis activity compared to the marketed product, Excised full thickness of the rat skins were mounted on Franz diffusion cells and the formulations were applied for 48 h. Greater skin permeation of Tacrolimus was detected from the NLCs hydro gel than from the commercial gel. Also higher retention was detected in the skin following NLCs hydro gel application Tacrolimus 0.5%gel containing Lipid nanoparticles are carriers with good prospects of successful marketing.
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| Keyword:
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Psoriasis, Tacrolimus, Nano lipid particles, entrapment efficiency, skin permeation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.186
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| Download:
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