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Effect of Lauric Oil Rich Tocotrienol and Squalene on Blood Lipid Profile in Rats
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| Author:
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M. NAINGGOLAN, A. G. S. SINAGA
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| Abstract:
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Oil palm (Elaeis guineensis Jacq.) and coconut (Cocos nucifer L.) are a member of the palm family (Arecaceae) and known as the oil-producing plant. Palm kernel produces palm kernel oil (PKO), while coconut milk produces virgin coconut oil (VCO). Both of oils called by lauric oil because containing above 50% of lauric acid. This research aims to study the effect of PKO and VCO on blood lipid and cholesterol profile. Palm kernel oil and virgin coconut oil was extraction by using cold-centrifuge processing method. Both oils were analyzed for a-tocotrienol, ?-tocotrienol, and squalene contents. Palm kernel olein and virgin coconut oil was administered orally at a dose 450 mg/kg.bw and 900 mg/kg.BW. for 4 weeks to analyzed blood lipid and cholesterol profile. The results showed that the yield of PKO was 24,45% and VCO was 20,85%. There was have a high content of lauric acid which is above 40%, but PKO has three times the content of oleic acid compared to VCO. The amount of a-tocotrienol in PKO was 4.46 ppm lower than VCO was 19.83 ppm, while amount of squalene in PKO was 47.11 ppm higher than VCO was 9.45 ppm. Giving VCO for 4 weeks could increase cholesterol level in the blood than PKO. The best cholesterol and HDL ratio in PKO with both doses. It is concluded that PKO is better than VCO to maintain blood lipid profile especially for increasing high density lipoprotein-cholesterol (HDLc) and decreasing low density lipoprotein-cholesterol (LDLc) and triglycerides amount in the blood.
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| Keyword:
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Palm kernel oil, virgin coconut oil, tocotrienol, squalene, lipid profile, cholesterol
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.179
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| Download:
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