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An Approach of resistance pattern of the four common antifungal drugs Griseofulvin, Terbinafine, Itraconazole and Fluconazole in patients having Dermatophytosis
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| Author:
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IDYENDRAN RUTHRAN, JESSIE JOSEPH
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| Abstract:
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The incidence of fungal infection is on the increase since 1950. The current focus of interest in research is the
antifungal susceptibility testing. The lack of a standardized method has led to inter-laboratory variation in the
absolute MIC of antifungal drugs. The clinical relevance of antifungal susceptibility testing in dermatophytosis
increases with the existence of a variety of effective antifungal drugs. The last fifteen years have witnessed marked
increase in the frequency of severe antifungal infections as well as in the number of available antifungal agents. The
filamentous fungi causes less invasive infections than those caused by the yeasts. However, the emergence of new
and less susceptible mould pathogens warrants the evaluation of their in vitro antifungal susceptibilities to both
established and investigational antifungal agents. Mc Nemar’s Chi-square test to compare the proportion of
symptoms before and after treatment demonstrated a p value <0.05 for all the four antifungal drugs ,signifying that
all had a therapeutic benefit in reducing the signs and symptoms. However Terbinafine group had greater
proportion of patients with absence of symptoms and signs.There was 100% reduction in erythema with the all
four antifungal drugs used in the study. At the end of follow up , greater proportion of patients in Terbinafine
group had resolution of desquamation (84%) as compared to itraconazole (52%), Griseofulvin (32%) and
Fluconazole (40%) while 16% in group A,48% in group B, 64% in group C and 60% in group D continued to have
desquamation at the end of treatment
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| Keyword:
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erbinafine, desquamation, itraconazole, Griseofulvin and Fluconazole
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| EOI:
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| DOI:
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