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A Study of Resistance To Systemic Antifungal Drugs And Its Clinical Correlation in Dermatophytosis
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| Author:
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RISWANA JASMINE. M, SUNDARAMORTHY SRINIVASAN
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| Abstract:
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The clinical types are TineaCapitis (scalp), Tineacorporis (body), Tineapedis (feet), Tineacruris (groin), and
Tineaunguium (nails). An increased prevalence of dermatophytosis is seen in India due to its hot and humid climate
and poor socioeconomic conditions leading to a lack of personal hygiene. Tineacorporis andTineacruris are the
most common types of dermatophytosis seen in India. A variety of antifungal drugs with less toxicity and better
pharmacokinetics are now available to treat dermatophytosis. With some exceptions (e.g., griseofulvin), the
antifungal drugs commonly used (Fluconazole, Itraconazole and Terbinafine) act against the ergosterol synthesis
pathway.However the emerging resistance to the common antifungal agents poses difficulty in the treatment of
these conditions. Though topical antifungal therapy have good efficacy in treating most superficial fungal infections,
severe infectionsand clinical types like Tineacapitis, Tineaunguium requires systemic therapy. Ininstruction to
envisage the therapeutic outcome of a given antimycotic agent used in the treatment of dermatophytosis, purpose
of the invitrodefenselessness of the drugs may demonstratecooperative. With dermatophytes, a good
associationamong the invitro data and clinical outcome has beenestablished for the , test and discdiffusion method.
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| Keyword:
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Tineacapitis, Tineaunguium,dermatophytes,microdilutionand discdiffusion method.
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| DOI:
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