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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Study of Resistance To Systemic Antifungal Drugs And Its Clinical Correlation in Dermatophytosis

Author: RISWANA JASMINE. M, SUNDARAMORTHY SRINIVASAN
Abstract: The clinical types are TineaCapitis (scalp), Tineacorporis (body), Tineapedis (feet), Tineacruris (groin), and Tineaunguium (nails). An increased prevalence of dermatophytosis is seen in India due to its hot and humid climate and poor socioeconomic conditions leading to a lack of personal hygiene. Tineacorporis andTineacruris are the most common types of dermatophytosis seen in India. A variety of antifungal drugs with less toxicity and better pharmacokinetics are now available to treat dermatophytosis. With some exceptions (e.g., griseofulvin), the antifungal drugs commonly used (Fluconazole, Itraconazole and Terbinafine) act against the ergosterol synthesis pathway.However the emerging resistance to the common antifungal agents poses difficulty in the treatment of these conditions. Though topical antifungal therapy have good efficacy in treating most superficial fungal infections, severe infectionsand clinical types like Tineacapitis, Tineaunguium requires systemic therapy. Ininstruction to envisage the therapeutic outcome of a given antimycotic agent used in the treatment of dermatophytosis, purpose of the invitrodefenselessness of the drugs may demonstratecooperative. With dermatophytes, a good associationamong the invitro data and clinical outcome has beenestablished for the , test and discdiffusion method.
Keyword: Tineacapitis, Tineaunguium,dermatophytes,microdilutionand discdiffusion method.
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