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Spectrophotometric Determination of Atenolol by Formation of Ion Association Complex
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| Author:
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SUHA ABDULLAH HUSSEIN, EMAN THIAB AL-SAMARRAI
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| Abstract:
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A simple, developed, fast and accurate spectrophotometric method to estimate Atenolol (ATL) in its pure form and pharmaceutical preparation (Tenordin). This method was based on the formation of an ionic duplication complex between ATL and the Bromocresol green (BCG) reagent to give a bluish-green color product that gives its highest absorption at the wavelength of 622 nm. The best conditions for complex formation were found (time, temperature, optimal reagent concentration, pH). The linearity of the method for the complex consisting ranged from 25-45 µg/ml, the Sandell's index was 0.140845 µg/cm2, and the molar absorption coefficient was 1890.73 L/mol.cm and the detection limit was 0.078810 µg /mL and the quantitative limit was 0.238819 µg/ml and the percent recovery rate was Rec% between (98.5602 - 100.3568)% and the relative standard deviation rate RSD% between (0.0721 - 0.2199)% It was found that the method is accurate and precision and has been successfully applied to estimate the ATL in its pharmaceutical preparation, in direct methods and in standard additions.
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| Keyword:
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Spectrophotometric determination, Atenolol, Ion Association
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.202
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| Download:
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