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Simultaneous Determination of Clopidogrel Bisulphate Based on Molecularly Imprinted Polymer and Its Pharmaceutical Application
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| Author:
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ASEEL SALAH MANSOOR, YEHYA KAMAL AL-BAYATI
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| Abstract:
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In the polymerization process, non-covalent molecularly imprinted polymers (MIP) were synthesized using clopidogrel bisulphate (Clop) as a template molecule, vinyl acetate (VA), 1-vinylimidizol (VIZ) as monomer, N, N-methylene bis-acrylamide (MBAA) as a cross-linker, and benzoyl peroxide (BPO) as an initiator. Four electrodes were synthesized using two different plasticizers, di-butyl subacute (DBS), di-octyl phthalate (DOP) in PVC matrix. Characterization of the obtained MIP was achieved by scanning electron microscopy (SEM), studying the electrodes properties, slope, detection limit, life time and linearity range the results showed that the membranes prepared gave linear range from (1×10-4-1×10-1, 1×10-3-1×10-1, 5×10-5-1×10-2and 5×10-5-1×10-2)M, respectively, with slops of (-17.94, -17.87, -17.68 and -18.2) as for the correlation coefficients are (0.9925, 0.9854, 0.9980 and 0.9886) and the detection limit it was (8.5×10-4, 8×10-4, 7×10-4and 8×10-4)M respectively. Selectivity coefficient of MIP measurements using different interfering species, the prepared electrodes was intended excellent for use in determining Clopidogrel bisulphate drug (Clop) in pharmaceutical sample.
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| Keyword:
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Molecularly impressed electrodes, Clopidogrel bisulphate (Clop), vinyl acetate (VA) monomer, 1-vinylimidizol (VIZ) monomer.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.199
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| Download:
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